Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women
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چکیده
منابع مشابه
Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women
Postmenopausal women with elevated serum sex steroids have an increased risk of breast cancer. Most of this risk is believed to be exerted through binding of the sex steroids to their receptors. For the first time, we investigate the association of estrogen receptor (ER) and androgen receptor (AR) serum bioactivity (SB) in addition to hormone levels in samples from women with breast cancer coll...
متن کاملRe: Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women.
BACKGROUND A positive relationship has generally been observed between plasma estrogen levels and breast cancer risk in postmenopausal women, but most of these studies have been small and few have evaluated specific estrogen fractions (such as percent bioavailable estradiol). In addition, few studies have evaluated plasma androgen levels in relation to breast cancer risk, and their results have...
متن کاملPlasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Background: A positive relationship has generally been observed between plasma estrogen levels and breast cancer risk in postmenopausal women, but most of these studies have been small and few have evaluated specific estrogen fractions (such as percent bioavailable estradiol). In addition, few studies have evaluated plasma androgen levels in relation to breast cancer risk, and their results hav...
متن کاملCyp17, urinary sex steroid levels and breast cancer risk in postmenopausal women.
Endogenous sex hormones play an important role in the etiology of breast cancer. Polymorphisms in genes encoding for enzymes involved in steroidogenesis may therefore play a role in breast cancer risk. Cytochrome P450c17alpha (Cyp17) functions at key branch points in human steroidogenesis. A T-->C transition (A1 and A2 allele) in the 5' untranslated region may be associated with increased expre...
متن کاملInterrelationship Between Alcohol Intake and Endogenous Sex-Steroid Hormones on Diabetes Risk in Postmenopausal Women.
OBJECTIVE We examined whether circulating concentrations of sex hormones, including estradiol, testosterone, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS), were associated with alcohol intake or mediated the alcohol-type 2 diabetes (T2D) association. METHODS Among women not using hormone replacement therapy and free of baseline cardiovascular disease, cancer,...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2011
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-11-0310